From the BBC News:

Researchers found a six-fold increase in the risk of developing Parkinson’s in individuals exposed in the workplace to trichloroethylene (TCE).

Although many uses for TCE have been banned around the world, the chemical is still used as a degreasing agent.

The research was based on analysis of 99 pairs of twins selected from US data records.

Parkinson’s can result in limb tremors, slowed movement and speech impairment, but the exact cause of the disease is still unknown, and there is no cure.

Research to date suggests a mix of genetic and environmental factors may be responsible. A link has previously been made with pesticide use.

‘Significant association’

The researchers from institutes in the US, Canada, Germany and Argentina, wanted to examine the impact of solvent exposure – specifically six solvents including TCE.

They looked at 99 sets of twins, one twin with Parkinson’s, the other without.

Because twins are genetically very similar or identical and often share certain lifestyle characteristics, twins were thought to provide a better control group, reducing the likelihood of spurious results.

The twins were interviewed to build up a work history and calculate likely exposure to solvents. They were also asked about hobbies.

The findings are presented as the first study to report a “significant association” between TCE exposure and Parkinson’s and suggest exposure to the solvent was likely to result in a six-fold increase in the chances of developing the disease.

The study also adjudged exposure to two other solvents, perchloroethylene (PERC) and carbon tetrachloride (CCl4), “tended towards significant risk of developing the disease”.

* * *

TCE has been used in paints, glue, carpet cleaners, dry-cleaning solutions and as a degreaser. It has been banned in the food and pharmaceutical industries in most regions of the world since the 1970s, due to concerns over its toxicity.

In 1997, the US authorities banned its use as an anaesthetic, skin disinfectant, grain fumigant and coffee decaffeinating agent, but it is still used as a degreasing agent for metal parts.

More.

Advertisements